The Cathedral Basilica of Saint Francis of Assisi, is a Roman Catholic cathedral in downtown Santa Fe, New Mexico. It is the mother church of the Archdiocese of Santa Fe.

The cathedral was built by Archbishop Jean Baptiste Lamy between 1869 and 1886 on the site of an older adobe church, La Parroquia (built in 1714-1717). An even earlier church on the same site, built in 1626, had been destroyed in the 1680 Pueblo Revolt. The new cathedral was built around La Parroquia, which was dismantled once construction was complete. A small chapel on the north side of the cathedral is all that remains of the old church.